Publications by authors named "D S Esmedlyaeva"
Extrapulmonary tuberculosis with a renal involvement can be a manifestation of a disseminated infection that requires therapeutic intervention, particularly with a decrease in efficacy of conventional regimens. In the present study, we investigated the therapeutic potency of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in the complex anti-tuberculosis treatment (ATT). A rabbit model of renal tuberculosis (rTB) was constructed by injecting of the standard strain Mycobacterium tuberculosis H37Rv into the cortical layer of the kidney parenchyma.
View Article and Find Full Text PDFComparison of Autografts and Biodegradable 3D-Printed Composite Scaffolds with Osteoconductive Properties for Tissue Regeneration in Bone Tuberculosis.
Biomedicines
August 2023
Tuberculosis remains one of the major health problems worldwide. Besides the lungs, tuberculosis affects other organs, including bones and joints. In the case of bone tuberculosis, current treatment protocols include necrectomy in combination with conventional anti-tuberculosis therapy, followed by reconstruction of the resulting bone defects.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the relationship between serum levels of metalloproteinases (MMPs) and their inhibitors in patients with infiltrative pulmonary tuberculosis (ITL) and how these levels change during intensive phase treatment (IPT).
- Results showed that specific MMP levels correlated with the severity and activity of tuberculosis, with notable increases in MMP-1 and MMP-9 while others remained stable or low.
- The findings suggest that monitoring MMP and acute-phase protein levels can improve predictions of IPT effectiveness and indicate ongoing reparative processes even after treatment.