Publications by authors named "D S Davydov"
Mobility control of CO is important for effective subsurface utilization and sequestration of anthropogenic CO in depleted formations. This not only enhances oil recovery but also increases CO storage efficiency, addressing a key challenge for a future zero-carbon economy. In this study, novel techniques were developed by injecting CO foam generated with a nonionic-based binary surfactant system to improve geological CO storage and to co-optimize carbon utilization and storage efficiency in high salinity carbonate porous media, based on hypotheses from our previous works.
View Article and Find Full Text PDFIn this study, to better understand the mechanisms of the profound impact of alcohol consumption on drug pharmacokinetics, efficacy, and toxicity, we characterized the alcohol-induced changes in the ensemble of drug-metabolizing enzymes and transporters (DMETs) in the human liver by performing global proteomic analysis of human liver microsomes from 94 donors. DMET protein levels were analyzed concerning alcohol consumption, smoking history, and sex using non-parametric tests, which were further strengthened by correlational analysis. To this end, we used a provisional index of alcohol exposure formulated based on the relative abundances of four marker proteins best correlating with the level of alcohol consumption.
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- * The research highlights how imbalances in cardiac preload and afterload affect blood pressure regulation in chronic pain patients, leading to increased cardiac strain and reduced venous blood return.
- * Findings suggest that this strain can increase susceptibility to tissue hypoperfusion and chronic inflammation, with potential applications for monitoring and diagnosing at-risk individuals through wearable technology.
Article Synopsis
- The study investigates how different P450 enzymes interact and affect drug metabolism changes due to alcohol by analyzing samples from 23 human liver donors with known alcohol consumption histories.
- Findings show a strong link between alcohol exposure and the metabolism rate of ketamine and amitriptyline, highlighting the increased importance of low-affinity enzymes post-alcohol consumption.
- The research indicates that while CYP3A4 is the main enzyme for metabolizing both drugs, several other enzymes displayed no positive correlation or even negative correlations with ketamine metabolism.