Enhanced antibody responses in CD19-Cre mice.

CD19-Cre is an important and widely used Cre-lox model for B cell-specific genetic manipulation in murine systems. Mice carrying one allele of CD19-Cre are, at the same time, rendered heterozygote for CD19, a crucial coreceptor of the B cell antigen receptor (BCR). As a result, CD19-Cre mice exhibit diminished expression levels of CD19, with potential, yet insufficiently examined, consequences in B cell activation.

Pesticide risk perception as an attitudinal mediator: Exploratory research with farm managers and consumers.

Pesticide use poses significant risks to human health and the environment. However, the public perception of pesticides is characterized by a number of factors, including risk perception. This study aimed to investigate the role of risk perception in two models: a) as a mediator between personal norms and pro-environmental attitudes of farm managers and b) as a mediator of trust in the purchase intention of consumers.

Beyond the Myths: Brazilian Consumer Perceptions of Functional Food.

The growing consumer interest in functional foods and healthy eating can unfortunately lead to the spread of misinformation and the belief in food-related myths. This study analyzed Brazilian consumers' perceptions and beliefs about facts and myths regarding functional foods, focusing on attitudes, reference groups, and sociocultural factors affecting their perception. A theoretical model was developed, incorporating constructs such as attitudes (reward, trust, necessity, safety), beliefs, and reference groups.

Sleep Quality among Older Adults in Brazil during the Coronavirus Disease 2019 Pandemic: The Role of Physical Activity.

 To assess sleep quality and sleepiness among older adults after social distancing during the coronavirus disease 2019 (COVID-19) pandemic and its association with physical activity.  The present cross-sectional study included a sample of 290 Brazilians aged ≥ 60 years. Subjective sleep quality and sleepiness were assessed using the Mini-Sleep Questionnaire (MSQ) and the Epworth Sleepiness Scale (ESS).

Electrochemical methods for evaluation of therapeutic monoclonal antibodies: A review.

Biopharmaceuticals are complex pharmaceutical drug products produced by biotechnology in living systems. Small changes in the production process can induce differences in the structure of the active ingredient, which may have a strong impact on its pharmacological properties. Therefore, quality assurance of biopharmaceuticals results in a high analytical effort.