Homeostatic regulation of a motor circuit through temperature sensing rather than activity sensing.

Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions represent some of the most common perturbations to neural function in animals.

Cellular and extracellular white matter alterations after childhood trauma experience in individuals with schizophrenia.

Background: Childhood trauma (CT) is related to altered fractional anisotropy (FA) in individuals with schizophrenia (SZ). However, it remains unclear whether CT may influence specific cellular or extracellular compartments of FA in SZ with CT experience. We extended our previous study on FA in SZ (Costello et al.

Deriving Mendelian Randomization-based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder.

Neuroanatomical variation in individuals with bipolar disorder (BD) has been previously described in observational studies. However, the causal dynamics of these relationships remain unexplored. We performed Mendelian Randomization of 297 structural and functional neuroimaging phenotypes from the UK BioBank and BD using genome-wide association study summary statistics.

Structural brain connectivity does not associate with childhood trauma in individuals with schizophrenia.

Background: Schizophrenia is a brain dysconnectivity disorder. However, it is not well understood whether the experience of childhood trauma (CT) affects dysconnectivity in individuals with schizophrenia (SZ). Using a network-based approach, we examined whether self-reported CT would explain additional variance compared to whole-brain topology and structural connectivity changes in SZ versus healthy controls (HC).