Publications by authors named "D S Belsky"
Background/objective: In a subset of participants from the CALERIE Phase 2 study we evaluated the effects of 2y of ~25% Calorie Restriction (CR) diet on IgG N-glycosylation (GlycAge), plasma and complement C3 N-glycome as markers of aging and inflammaging.
Methods: Plasma samples from 26 participants in the CR group who completed the CALERIE2 trial and were deemed adherent to the intervention (~>10 % CR at 12 mo) were obtained from the NIA AgingResearchBiobank. Glycomic investigations using UPLC or LC-MS analyses were conducted on samples from baseline (BL), mid-intervention (12 mo) and post-intervention (24 mo), and changes resulting from the 2y CR intervention were examined.
Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n = 218 participants during the trial.
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- - A survey of aging researchers revealed significant disagreement on key questions about aging, such as its definition, causes, onset, and rejuvenation, indicating a lack of consensus in the field.
- - Researchers have varying interpretations of what constitutes "aging," leading to different experimental approaches and priorities, which complicates the understanding and study of the aging process.
- - The findings highlight the necessity for clearer definitions and targeted goals within aging research, as well as strategies to address ongoing disagreements, in hopes of advancing the field.
Background: The association between ultra-processed food (UPF) intake and markers of biological ageing has been scarcely investigated, despite the evident adverse health effects associated with UPF. This study aimed to test the association between UPF intake and biological ageing, and evaluate how much of this association is accounted for by overall diet quality.
Methods: This cross-sectional study assessed 16 055 participants aged 20-79 years (51% women, 46 ± 0.
Article Synopsis
- - The geroscience hypothesis suggests that biological aging contributes significantly to cognitive decline.
- - Analyzed data from the Framingham Heart Study linked faster aging (measured by the DunedinPACE epigenetic clock) to poorer cognitive performance and quicker decline over two decades.
- - Findings indicate that biological aging metrics can help identify individuals at risk for cognitive decline, which may enhance risk assessment in clinical settings and future trials.