Publications by authors named "D S Auld"
Article Synopsis
- 4-cresol, a substance linked to health benefits in diabetes, enhances insulin sensitivity in mouse myoblasts and boosts insulin secretion in isolated mouse islets.
- The compound demonstrates minimal off-target effects and binds primarily to specific kinases like RPS6KA3, which are important in pancreatic islet function.
- Research indicates that 4-cresol may improve glycemic control and β-cell activity, highlighting its potential role in diabetes treatment.
Microbes Causing Spinal Epidural Infection in Patients Who Use Drugs.
Open Forum Infect Dis
October 2024
Background: The incidence of spine infections has increased due to the surge in injection drug use driven by the opioid epidemic. Few recent studies have evaluated the microbiology of spinal epidural infections among people who inject drugs compared to the microbiology of such infections among the general population.
Methods: We performed a retrospective chart review to identify patients with a spinal epidural abscess or phlegmon unrelated to recent spine surgery between 2015 and 2023.
Article Synopsis
- Cerebral small vessel disease (cSVD) is a major contributor to stroke and dementia, and currently lacks specific treatments, prompting a study using Mendelian randomization to identify protein associations.
- The research combined cerebrospinal fluid (CSF) and plasma data with genetic studies to identify 49 proteins linked to cSVD, highlighting 16 that appeared in both fluids and showing connections to immune response and extracellular matrix pathways.
- Notably, many identified proteins were associated with stroke and dementia, with some already having known drug targets, paving the way for potential new biomarkers and therapies for cSVD.
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer's disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of asymptomatic but "at risk" individuals (PREVENT-AD) were used to explore the relationship between PTPRS and various Alzheimer's disease biomarkers. We identified that PTPRS rs10415488 variant C shows features of neuroprotection against early Tau pathology and synaptic degeneration in Alzheimer's disease.
View Article and Find Full Text PDF