Psychiatric hospitalizations in a cohort of Danish polio patients.

Although previous polio infection remains a considerable cause of long-term morbidity worldwide, few studies have examined the psychiatric consequences of poliomyelitis. The authors followed 4,660 polio patients hospitalized at the primary infectious disease hospital in Copenhagen, Denmark, between 1922 and 1954 as well as 19,017 age- and gender-matched Danes for psychiatric hospitalizations from January 1, 1977, to December 31, 1993. Incidence rates of all psychiatric disorders combined and of separate diagnostic groups of psychiatric diseases in the two cohorts were compared, yielding the incidence rate ratio, a measure of relative risk.

Unchanged acetylation of isoniazid by alcohol intake.

Setting: In 10 healthy subjects, the influence of acute alcohol intake on the pharmacokinetics of isoniazid (INH) was studied.

Objective: To test the hypothesis that alcohol increases the conversion of INH by acetylation into its metabolite acetylisoniazid.

Design: In a crossover design, an oral dose of 300 mg INH was administered on 2 separate days, 14 days apart, with or without alcohol to a serum alcohol of about 21 mmol/l (1 g/l) maintained for 12 h.

Life-long morbidity among Danes with poliomyelitis.

Objective: To estimate long-term morbidity in a cohort of Danish poliomyelitis patients.

Design: A historical prospective cohort study of 27,047 persons.

Setting: Denmark.

Long-term mortality after poliomyelitis.

Background: Few studies have described mortality and cause of death among persons with a history of polio.

Methods: We identified a group of patients diagnosed with poliomyelitis in Copenhagen between 1919 and 1954. We obtained information on vital status through May 1997 and on cause of death by linkage with the Danish Civil Registration System and the Danish Cause-of-Death Register.