Cardiomyocytes (CMs) lost during ischemic cardiac injury cannot be replaced due to their limited proliferative capacity. Calcium is an important signal transducer that regulates key cellular processes, but its role in regulating CM proliferation is incompletely understood. Here we show a robust pathway for new calcium signaling-based cardiac regenerative strategies.
View Article and Find Full Text PDFObjectives: This study assessed how exposure to slow (SBM) versus fast beat music (FBM) during high-intensity rowing intervals affects performance, heart rate (HR), lactate levels, relative perceived exertion (RPE), and recovery.
Methods: The A/B crossover design involved 21 participants performing 5 × 500 m rowing intervals under two conditions: FBM and SBM. Primary endpoint was the difference in total rowing time.
L-type CaV1.2 current (ICa,L) links electrical excitation to contraction in cardiac myocytes. ICa,L is tightly regulated to control cardiac output.
View Article and Find Full Text PDFObjectives: To date there is no universally accepted model that describes the development of substance related addictive behavior. In order to address this gap, the study sought to examine whether the association between primary emotions and the inclination toward addictive behavior is mediated by an anxious attachment style.
Methods: The total sample consisted of 900 German speaking non-clinical adults (age: = 27; = 9.