Publications by authors named "D S Andersen"
Urbanization impacts the structure and viability of wildlife populations. Some habitat generalists, such as bobcats (Lynx rufus), maintain populations at the intersection of wild and urban habitats (wildland urban interface, WUI), but impacts of urbanization on bobcat social structure are not well understood. Although commonly thought to establish exclusive home ranges among females, instances of mother-daughter home range sharing have been documented.
View Article and Find Full Text PDFBoth the clinical management and study of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) is complicated by significant heterogeneity in the etiology, mechanisms, symptoms, and complications of pancreatitis. The National Institutes of Diabetes and Digestive and Kidney Disease (NIDDK) recently convened a workshop to address current knowledge and knowledge gaps in the field. Preclinical models that better replicate human disease are important for development of new therapies.
View Article and Find Full Text PDFPurpose: Carbonic anhydrase IX (CAIX) is a well-established prognostic marker in breast cancer (BC). Nevertheless, this prognostic value is yet to be confirmed in BC subtypes. This study aims to investigate the prognostic effects of CAIX in oestrogen receptor (ER)-negative (ER-) BCs and to establish pathways related to cytoplasmic CAIX expression in ER- and lymph node-negative BCs.
View Article and Find Full Text PDFNo Clinical Efficacy of Adipose-Derived Regenerative Cells and Lipotransfer in Breast Cancer-Related Lymphedema: A Double-Blind Placebo-Controlled Phase II Trial.
Plast Reconstr Surg
December 2024
Article Synopsis
- Breast cancer-related lymphedema (BCRL) affects about 1 in 3 survivors, with current treatments not addressing the root cause; studies suggest adipose-derived regenerative cells (ADRCs) and lipotransfer might help.
- A randomized, double-blind trial involved 80 patients with persistent BCRL, comparing ADRCs and lipotransfer against a placebo to measure changes in lymphedema volume and quality of life after one year.
- Results showed no objective differences between treatment and placebo groups, although both reported subjective improvements; the study concludes that ADRC and lipotransfer are not beneficial for BCRL, but suggests further research might be needed with different dosages or repeated treatments.
Background: Injection of autologous adipose-derived regenerative cells (ADRCs) combined with lipotransfer has been suggested to alleviate symptoms in diseases including breast cancer-related lymphedema (BCRL). We recently performed a randomized controlled trial injecting lipoaspirate with ADRCs into the axilla of BCRL patients, and here we aimed in the intervention group to define in an unbiased fashion whether ADRC injection was linked to the clinical outcome.
Methods: 39 BCRL patients received lipotransfer assisted with autologous ADRCs (4.