Publications by authors named "D Ruiz-Vilchez"
The socioeconomic status of patients with ankylosing spondylitis and its association with the burden of the disease and permanent disability: a cross-sectional cluster analysis.
Ther Adv Musculoskelet Dis
September 2024
Background: Few studies have been conducted to investigate the socioeconomic profiles of patients with ankylosing spondylitis (AS) and their associations with disease severity and disability.
Objectives: The objectives of this study were to identify clusters of patients with AS according to their socioeconomic characteristics and to evaluate the associations between these clusters and the severity of the disease and permanent disability.
Design: This was a cross-sectional and multicentre study.
Personalized cardiovascular risk assessment in Rheumatoid Arthritis patients using circulating molecular profiles and their modulation by TNFi, IL6Ri, and JAKinibs.
Biomed Pharmacother
April 2024
Article Synopsis
- The study investigated the inflammatory profiles of Rheumatoid Arthritis (RA) patients to identify those at higher risk for cardiovascular (CV) issues and evaluated the effects of specific medications.
- Researchers analyzed data from 387 RA patients, dividing them into groups based on prior CV events and treatment with disease-modifying drugs, while examining various inflammatory biomarkers.
- Findings revealed three distinct RA patient groups with varying inflammatory levels and CV risks, highlighting that certain treatments effectively lowered disease activity and improved inflammatory markers associated with CV risk, suggesting a pathway for personalized management in RA care.
Objective: To describe the frequency of malnutrition in older patients with rheumatoid arthritis (RA) and investigate associated risk factors.
Methods: This multicenter, cross-sectional study included participants aged ≥65 years who met the 2010 ACR/EULAR criteria for RA. Nutritional status was assessed using the Mini Nutritional Assessment Short Form (MNA-SF) and based on variables, such as albumin level, the Geriatric Nutritional Risk Index (GNRI), and vitamin D.
Objective: To describe the prevalence of sarcopenia in rheumatoid arthritis (RA) patients aged ≥65 years and identify the risk factors associated with sarcopenia.
Methods: This is a multicenter, controlled, cross-sectional study of 76 RA patients and 76 age- and sex-matched healthy controls. Sarcopenia was defined according to the revised criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2).
Objective: We analyzed NAD metabolism in patients with rheumatoid arthritis (RA), its association with disease activity and clinical outcomes of RA, and the therapeutic potential of pharmacologic NAD boosting.
Methods: Our study included 253 participants. In the first cohort, comprising 153 RA patients and 56 healthy donors, we assessed NAD levels and NAD -related gene pathways.