Stressful family life events and father involvement in Korean children's sociobehavioral health.

We examined the longitudinal associations between stressful family life events at 4 years of age and children's internalizing and externalizing behaviors at 7 years of age, whether family functioning and parental warmth (i.e., mothers' warmth, fathers' warmth) mediated those associations, and whether the associations varied by fathers' involvement in Korean families.

Performance Evaluation of 2 FDA-Approved Fentanyl Immunoassays against LC-MS/MS Reference.

Background: Fentanyl, a synthetic opioid, has caused many recent overdose deaths. Diagnosis of fentanyl abuse is not served by traditional opiate assays due to differences in chemical structure between synthetics and natural opioids. To our knowledge, this is the first study that uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the reference method to evaluate and compare the ARK Fentanyl II Assay (ARK II) and the Fentanyl II Enzyme Immunoassay by Roche (FEN2).

Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine.

We present a quantitative clinical LC-MS/MS assay for the simultaneous analysis of buprenorphine, norbuprenorphine, and their glucuronide metabolites in human urine. The assay is based on the direct and hydrolysis-free sample preparation protocol, i.e.

South Korean adolescents' delinquency, disclosure, parental knowledge, parent-child closeness, and delinquent peer associations.

The present study sought to examine longitudinal associations among delinquency, children's disclosure to parents, parent-child relationship quality, and parental knowledge in a South Korean sample. Longitudinal research shows that in Western samples, delinquency is negatively associated with the latter three variables. We also sought to test whether the associations varied across gender.

Hypertension update, JNC8 and beyond.

Hypertension is the most preventable major risk factor for cardiovascular morbidity and mortality. The etiology of elevated blood pressure is a complex process involving the interaction of genetics, demographics, comorbid disorders, and environmental influences. Effective hypertensive therapy has been shown to reduce cardiovascular morbidity and mortality.