Publications by authors named "D Royston"
Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. Most patients present with early-stage disease, but a substantial proportion progress to myelofibrosis or secondary leukemia, advanced cancers with a poor prognosis and high symptom burden. Currently, it remains difficult to predict progression, and therapies that reliably prevent or reverse fibrosis are lacking.
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- Diagnosis of essential thrombocythaemia (ET) is difficult for patients without specific genetic mutations, prompting a study of 320 'triple-negative thrombocytosis' patients to evaluate bone marrow histology and a myeloid gene panel.
- Histology showed that 36.8% of patients had supportive findings indicating myeloproliferative neoplasm, correlating with higher platelet counts, while only 14.6% of gene tests revealed significant variants.
- The study emphasizes the importance of histology in diagnosing 'triple-negative' ET, highlighting the need for caution when relying on myeloid gene panel results and suggesting the development of specific guidelines for such cases.
This case report describes the case of a man in his seventies presenting with a nasopharyngeal deposit of myeloid sarcoma associated with acute monomyelocytic leukaemia. He presented with right nasal obstruction associated with unilateral pulsatile tinnitus. CT and MRI scans of sinuses identified a moderately restricting mucosal swelling of the right torus tubarius, and a biopsy of the lesion diagnosed a nasal deposit of myeloid sarcoma.
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