Thermal energy analysis of N-nitroso compounds, including ureas, urethanes and guanidines.

Simple, selective, sensitive analytical methods have been developed for a number of N-nitroso compounds (NOC) which are applicable to environmental and biological matrices and have been used to quantify nitrosourea anticancer drugs in human plasma. These new chromatographic detection windows can be used to screen suspect matrices for NOC.

A new Thermal Energy Analyzer for direct high-performance liquid chromatographic and gas chromatographic analysis of N-nitrosamides.

The Thermal Energy Analyzer (TEA) has been modified to make it capable of detecting compounds such as N-nitrosamides. This modified TEA(amide) can be used with both gas chromatography (GC) and high-performance liquid chromatography (HPLC). Analysis of underivatized N-nitroso amides by GC-TEA(amide) and HPLC-TEA(amide) are also described.