Publications by authors named "D Rosiak"
Article Synopsis
- The crystal structures of two new oxidovanadium(IV) salts were identified, along with their cytotoxic effects on prostate and breast cancer cells.
- Four N-heterocyclic salts showed strong cytotoxic action on both cancerous and normal cells.
- The compounds' effectiveness varied based on the structure of the counterion, with one specific compound demonstrating the highest activity, while another exhibited the lowest toxicity and distinct effects on cell cycle distribution in cancer cells.
By the reaction of benzoyl chloride, potassium isothiocyanate and the appropriate halogenoaniline, i.e. 2/3/4-(bromo/iodo)aniline, we have obtained five new 1-benzoyl-3-(halogenophenyl)thioureas, namely, 1-benzoyl-3-(2-bromophenyl)thiourea and 1-benzoyl-3-(3-bromophenyl)thiourea, CHBrNOS, and 1-benzoyl-3-(2-iodophenyl)thiourea, 1-benzoyl-3-(3-iodophenyl)thiourea and 1-benzoyl-3-(4-iodophenyl)thiourea, CHINOS.
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View Article and Find Full Text PDFImpact of the anion and chalcogen on the crystal structure and properties of 4,6-dimethyl-2-pyrimido(thio)nium halides.
Acta Crystallogr C Struct Chem
May 2020
By the reaction of urea or thiourea, acetylacetone and hydrogen halide (HF, HBr or HI), we have obtained seven new 4,6-dimethyl-2-pyrimido(thio)nium salts, which were characterized by single-crystal X-ray diffraction, namely, 4,6-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium bifluoride, CHNO·HF or (dmpH)FH, 4,6-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium bromide, CHNO·Br or (dmpH)Br, 4,6-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium iodide, CHNO·I or (dmpH)I, 4,6-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium iodide-urea (1/1), CHNO·I·CHNO or (dmpH)I·ur, 4,6-dimethyl-2-sulfanylidene-2,3-dihydropyrimidin-1-ium bifluoride-thiourea (1/1), CHNS·HF·CHNS or (dmptH)FH·tu, 4,6-dimethyl-2-sulfanylidene-2,3-dihydropyrimidin-1-ium bromide, CHNS·Br or (dmptH)Br, and 4,6-dimethyl-2-sulfanylidene-2,3-dihydropyrimidin-1-ium iodide, CHNS·I or (dmptH)I. Three HCl derivatives were described previously in the literature, namely, 4,6-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium chloride, (dmpH)Cl, 4,6-dimethyl-2-sulfanylidene-2,3-dihydropyrimidin-1-ium chloride monohydrate, (dmptH)Cl·HO, and 4,6-dimethyl-2-sulfanylidene-2,3-dihydropyrimidin-1-ium chloride-thiourea (1/1), (dmptH)Cl·tu. Structural analysis shows that in 9 out of 10 of these compounds, the ions form one-dimensional chains or ribbons stabilized by hydrogen bonds.
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