DIKEDOC: a multicriteria methodology to organise and communicate knowledge.

DIKEDOC is a knowledge-based multicriteria methodology that is here proposed to organise dispersed knowledge about a complex problem when a decision process has not yet been activated, or is latent, and to generate an interaction space that produces new knowledge. An integrated use of logical and analytical tools is proposed, first for use at a technical level to organise any dispersed knowledge in a way that generates insights that can be communicated, and then in a participative context, to create an opportunity to interact, share personal points of view and experiences and to explore spaces of action, where such tools facilitate understanding, criticism and proposals. A pilot study was developed, by an interdisciplinary research team, in relation to the enhancement process of the "Ivrea, industrial city of the twentieth century" UNESCO site, which still needs to be activated after a long and complex decision process that led to the inclusion of the site in the World Heritage List.

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function.

Impaired pancreatic β-cell function and insulin secretion are hallmarks of type 2 diabetes. miRNAs are short, noncoding RNAs that silence gene expression vital for the development and function of β cells. We have previously shown that β cell-specific deletion of the important energy sensor AMP-activated protein kinase (AMPK) results in increased miR-125b-5p levels.

Evaluating the impact of housing market liberalization on the timing of marriage: Evidence from Egypt.

The transition to adulthood around the world is increasingly characterized by young people's desire to form independent households. Forming such households in Egypt requires buying or building a dwelling or obtaining a rental unit. Policies governing housing markets, such as rent control, and limited financing options have historically made access to housing for young couples challenging.

The Long-Term Effects of Time Use during High School on Positive Development.

This longitudinal study examines how the time that youth spend in activities during high school may contribute to positive or negative development in adolescence and in early adulthood. We draw on data from 1103 participants in the longitudinal Youth Development Study, followed from entry to high school to their mid-twenties. Controlling demographic, socioeconomic, and psychological influences, we estimate the effects of average time spent on homework, in extracurricular activities, and with friends during the four years of high school on outcomes measured in the final year of high school and twelve years later.