Publications by authors named "D Rodriguez-Alcalde"
Objective: In patients with iron deficiency anaemia (IDA), the diagnostic yield of gastroscopy and colonoscopy (bidirectional endoscopy) in detecting neoplastic lesions is low. This study aimed to develop and validate a faecal immunochemical test (FIT)-based model to optimise the work-up of patients with IDA.
Methods: Outpatients with IDA were enrolled in a prospective, multicentre study from April 2016 to October 2019.
Article Synopsis
- There are clear guidelines for hereditary diffuse gastric cancer, but not for familial intestinal gastric cancer (FIGC), leading to uncertainty about how to check for it.
- A study in Spain looked at families with FIGC to find out how often they should have endoscopies (a test doctors use to look at the stomach).
- They found that many people in these families had early signs of stomach cancer and that the bacteria Helicobacter pylori increases the risk of those signs appearing.
Background: Patients with serrated polyposis syndrome (SPS) have multiple and/or large serrated colonic polyps and higher risk for colorectal cancer. SPS inherited genetic basis is mostly unknown. We aimed to identify new germline predisposition factors for SPS by functionally evaluating a candidate gene and replicating it in additional SPS cohorts.
View Article and Find Full Text PDFBackground: The major limitation of piecemeal endoscopic mucosal resection (EMR) is the inaccurate histological assessment of the resected specimen, especially in cases of submucosal invasion.
Objective: To classify non-pedunculated lesions ≥20 mm based on endoscopic morphological features, in order to identify those that present intramucosal neoplasia (includes low-grade neoplasia and high-grade neoplasia) and are suitable for piecemeal EMR.
Design: A post-hoc analysis from an observational prospective multicentre study conducted by 58 endoscopists at 17 academic and community hospitals was performed.
Serrated polyposis syndrome (SPS) implies a slightly elevated risk of colorectal cancer (CRC) during endoscopic follow-up, but its natural course is still not well known. The main objective of this study was to describe the long-term risk of developing advanced neoplasia (AN) in these patients. Until October 2020, individuals who fulfilled 2010 WHO criteria I and/or III for SPS were retrospectively recruited.
View Article and Find Full Text PDF