Nonnegative matrix factorization for analyzing state dependent neuronal network dynamics in calcium recordings.

Calcium imaging allows recording from hundreds of neurons in vivo with the ability to resolve single cell activity. Evaluating and analyzing neuronal responses, while also considering all dimensions of the data set to make specific conclusions, is extremely difficult. Often, descriptive statistics are used to analyze these forms of data.

A data augmentation procedure to improve detection of spike ripples in brain voltage recordings.

Epilepsy is a major neurological disorder characterized by recurrent, spontaneous seizures. For patients with drug-resistant epilepsy, treatments include neurostimulation or surgical removal of the epileptogenic zone (EZ), the brain region responsible for seizure generation. Precise targeting of the EZ requires reliable biomarkers.

Inhibitor development according to concentrate after 50 exposure days in severe hemophilia: data from the European HAemophilia Safety Surveillance (EUHASS).

Background: Patients with hemophilia have a life-long risk of developing neutralizing antibodies (inhibitors) against clotting factor concentrates. After the first 50 exposure days (EDs), ie, in previously treated patients (PTPs), data on inhibitor development are limited.

Objectives: To report inhibitor development according to factor (F)VIII or FIX concentrate use in PTPs with severe hemophilia A and B.

Non-Negative Matrix Factorization for Analyzing State Dependent Neuronal Network Dynamics in Calcium Recordings.

Calcium imaging allows recording from hundreds of neurons with the ability to resolve single cell activity. Evaluating and analyzing neuronal responses, while also considering all dimensions of the data set to make specific conclusions, is extremely difficult. Often, descriptive statistics are used to analyze these forms of data.

Burden Predictors for Informal Caregivers of Older Adults in Spain: The Role of Cohabitation, Coping Strategies, Social Support, and Evaluation of Preexisting Relationships.

Given the role that informal caregivers play in caring for older adults and the importance of understanding the variables that may predict the burden that they experience due to caregiving, the aim of this article is to examine the relationship between different variables and the caregiver's subjective burden. Authors examined the relationship between caregivers' sociodemographic characteristics (age and gender), the context in which the care is provided (cohabiting or not), duty as a reason for taking on the role of caregiver, the evaluation of the preexisting relationship between caregiver and care recipient, as well as coping strategies and social support as predictor variables of subjective burden. For this purpose, 161 caregivers of older Spanish adults completed a questionnaire containing information on the corresponding variables.