Publications by authors named "D Robledo"
Article Synopsis
- Ataxia telangiectasia (A-T) is a rare genetic disorder that leads to neurological issues, immune system problems, cancer risk, and other health concerns due to a mutation in the ATM protein, which is crucial for responding to DNA damage.
- CD98HC is a protein that helps transport amino acids in cells, and when ATM is not functioning properly, it affects the transporters linked to A-T symptoms, leading to issues like telangiectasia and diabetes.
- Research shows that addressing the amino acid transport imbalance can help restore metabolic health in cells lacking ATM, highlighting the potential benefits of N-acetyl cysteine in reducing toxic glutamate levels and improving overall cell function in A-T patients.
Article Synopsis
- Salmonid species respond differently to sea lice, with Atlantic salmon suffering from parasitism and coho salmon showing near-complete resistance due to unique biological pathways.
- Research utilized single-nuclei RNA sequencing to analyze cellular and molecular responses in both species after exposure to sea lice, revealing a common immune response but a greater effectiveness in coho salmon.
- Findings emphasize the critical role of keratinocytes in coho salmon's resistance, identifying potential pathways and genes for biotechnological advancements to enhance Atlantic salmon's defense against sea lice.
The tiger pufferfish (), also known as fugu, has recently suffered from severe infections under aquaculture environment, yet the underlying immune mechanisms against the parasite remain poorly understood. In this study, we conducted a comprehensive transcriptome analysis of the gill tissue from infected and uninfected fish using PacBio long-read (one pooled sample each for seriously infected and healthy individuals, respectively) and Illumina short-read (three pools for mildly infected, seriously infected, and healthy individuals, respectively) RNA sequencing technologies. After aligning sequence data to fugu's reference genome, 47,307 and 34,413 known full-length transcripts were identified and profiled in healthy and infected fish, respectively.
View Article and Find Full Text PDFBioelectricity is an interdisciplinary concept that encompasses the fields of chemistry, physics, and biology. It is the scientific study of membrane transport mechanisms that govern the formation and dissipation of ion gradients. Teaching and learning across disciplines, such as bioelectricity, are known among science teachers to be challenging and complex.
View Article and Find Full Text PDFSingle cell genomics encompasses a suite of rapidly maturing technologies that measure the molecular profiles of individual cells within target samples. These approaches provide a large up-step in biological information compared to long-established 'bulk' methods that profile the average molecular profiles of all cells in a sample, and have led to transformative advances in understanding of cellular biology, particularly in humans and model organisms. The application of single cell genomics is fast expanding to non-model taxa, including aquaculture species, where numerous research applications are underway with many more envisaged.
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