OUTLINING THE ABSENCE: FROM INFLAMMATION TO A DISTINCT ENDOPHENOTYPE FOR THE NEGATIVE SYMPTOMS OF SCHIZOPHRENIA.

The concept of schizophrenia as a mental condition is subject to deconstruction for a broader approach toward a systemic disorder by encompassing the links with inflammation. Beyond the salient psychotic symptoms of schizophrenia, the negative symptoms remain the silent cause of deterioration and the hallmark of a worse prognosis. Either as part of a unitary disorder or as a distinct subtype of schizophrenia, the negative symptoms seem to be associated with specific biological features.

The familiarity of Romanian psychiatrists with anti-N-methyl-D-aspartate receptor encephalitis: findings from a web-based survey study.

Background And Aims: Psychiatrists are often the first to be consulted in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Thus, they need to be aware of clinical features, differential diagnoses, and treatment options for this condition. In this study, we aimed to investigate the familiarity of Romanian psychiatrists with anti-NMDAR encephalitis.

Enhancing Comprehensive Assessments in Chronic Heart Failure Caused by Ischemic Heart Disease: The Diagnostic Utility of Holter ECG Parameters.

: Chronic heart failure (CHF) caused by ischemic heart disease (IHD) is the leading cause of death worldwide and presents significant health challenges. Effective management of IHD requires prevention, early detection, and treatment to improve patient outcomes. This study aims to expand the diagnostic utility of various 24 h Holter ECG parameters, such as T-wave alternans (TWA), late ventricular potentials (LVPs), and heart rate variability (HRV) in patients with CHF caused by IHD.

Neural Antibodies in First-episode Psychosis Patients with Warning Signs for Autoimmune Encephalitis.

Objective: : Autoimmune encephalitis (AE) remains an essential differential diagnosis in patients with first-episode psychosis (FEP). In this study, we aimed to assess to prevalence of AE in a cohort of FEP patients.

Methods: : We used a phenotype-driven algorithm to detect AE in patients with FEP.

The relevance of anti-N-methyl-D-aspartate receptor encephalitis for psychiatrists.

Psychiatrists are often the first to be consulted in patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. While this disease is rare, psychiatrists need to be aware of its relevant fundamental, clinical and therapeutic aspects. We begin by reviewing the connection between anti-NMDAR encephalitis and the glutamate hypothesis of schizophrenia.