Predictive and Prognostic Factors in Melanoma Central Nervous System Metastases-A Cohort Study.

Background: Melanoma is the cancer with the highest risk of dissemination to the central nervous system (CNS), one of the leading causes of mortality from this cancer.

Objective: To identify patients at higher risk of developing CNS metastases and to evaluate associated prognostic factors.

Methods: A cohort study (1998-2023) assessed patients who developed CNS melanoma metastases.

Prurigiform Angiomatosis: A New Term for Describing the Prominent Dermal Angiomatoid Proliferation Underlying Epidermal Changes in Prurigo Nodularis/Lichen Simplex Chronicus.

Vascular hyperplasia is a common finding in prurigo nodularis/lichen simplex chronicus (LSC). The term prurigiform angiomatosis was recently proposed to describe a histologic pattern characterized by prominent vascular hyperplasia in patients with LSC. The aim of this study was to identify cases of LSC with this pattern and analyze associations with clinical and pathologic features and disease course.

Childhood Vulvar Mucous Membrane Pemphigoid.

Background: Autoimmune bullous diseases in childhood are a diagnostic challenge.

Case: We present the case of an 11-year-old girl with recurrent vulvar erosions since early childhood. She had been referred to a child abuse unit under the suspicion of sexual abuse.