Publications by authors named "D Richard"
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
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- - A survey of aging researchers revealed significant disagreement on key questions about aging, such as its definition, causes, onset, and rejuvenation, indicating a lack of consensus in the field.
- - Researchers have varying interpretations of what constitutes "aging," leading to different experimental approaches and priorities, which complicates the understanding and study of the aging process.
- - The findings highlight the necessity for clearer definitions and targeted goals within aging research, as well as strategies to address ongoing disagreements, in hopes of advancing the field.
Article Synopsis
- - Breast cancer (BCa) presents a significant health challenge worldwide, with many tumors showing extensive genetic alterations known as somatic copy number alterations (CNAs) that influence tumor behavior and patient outcomes.
- - Loss of the chromosome segment 13q14.2 is a common and important CNA found in up to 63% of BCa patients, associated with poorer survival rates, and its impact is complex, enhancing both cancer cell growth and immune responses in the tumor environment.
- - This loss of 13q14.2 also increases the effectiveness of BCL2 inhibitors in treating BCa, suggesting it could be used as a biomarker to help predict patient prognosis and guide treatment options.
Public health practitioners rely on timely surveillance data for planning and decision-making; however, surveillance data are often subject to delays. Epidemic trend categories, based on time-varying effective reproductive number (R) estimates that use nowcasting methods, can mitigate reporting lags in surveillance data and detect changes in community transmission before reporting is completed. CDC analyzed the performance of epidemic trend categories for COVID-19 during summer 2024 in the United States and at the state level in New Mexico.
View Article and Find Full Text PDFPeripheral nervous system (PNS) toxicity assessment in non-clinical safety studies is challenging and relies mostly on histopathological assessment. The present work aims to identify blood-based biomarkers that could detect peripheral neuropathy in rats upon exposure to neurotoxic compounds. Three anticancer agents (oxaliplatin, cisplatin, paclitaxel) and a developmental compound (NVS-1) were assessed in male rats (Wistar Han).
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