Atrophic Facial Plaque in a 4-Month-Old Male: An Unusual Presentation of Hair Follicle Nevus.

Hair follicle nevus is a rare benign follicular hamartoma that is characterized histologically by the proliferation of vellus hair follicles with peri-follicular fibrous thickening. Clinically, hair follicle nevus is most commonly reported as an asymptomatic papule or nodule on the head and neck. Here, we describe an unusual presentation of hair follicle nevus presenting as an atrophic plaque on the cheek of a male infant.

Direct glycosylation analysis of intact monoclonal antibodies combining ESI MS of glycoforms and MALDI-in source decay MS of glycan fragments.

Monoclonal antibody (mAb) glycoengineering has the potential to improve the efficacy of biopharmaceuticals by fine-tuning specific biological properties. Glycosylation analysis is key to monitoring the glycoengineering process. Various mass spectrometry (MS)-based methods are available to characterize mAb glycosylation at different structural levels, but comprehensive analysis is typically time-consuming and costly.

Risk factors and outcomes of melanoma in children and adolescents: A retrospective multicenter study.

Background: Pediatric melanoma presents with distinct clinical features compared to adult disease.

Objective: Characterize risk factors and negative outcomes in pediatric melanoma.

Methods: Multicenter retrospective study of patients under 20 years diagnosed with melanoma between January 1, 1995 and June 30, 2015 from 11 academic medical centers.