Beyond Connectivity: Exploring the Influence of Digital Access on the Social Determinants of Health for Youth in Out-of-Home Care.

This study explores digital inclusion for youth in out-of-home placement within the child welfare system, a group impacted by significant social determinants affecting health. Recognized as a "super social determinant of health," digital inclusion holds promise in addressing key health factors, such as social relationships, support systems, and information access. The study surveyed 131 foster parents and 152 kinship providers across varied U.

Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function.

Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K precursor [menadione sodium bisulfite (MSB)] suppresses PC progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation of key cysteines, pointing to a redox checkpoint in sorting.

Evocative effects on the early caregiving environment of genetic factors underlying the development of intellectual and academic ability.

This study examined gene-environment correlation (rGE) in intellectual and academic development in 561 U.S.-based adoptees (57% male; 56% non-Latinx White, 19% multiracial, 13% Black or African American, 11% Latinx) and their birth and adoptive parents between 2003 and 2017.