Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low-calorie diet.

The endocrine consequences of weight loss by bariatric surgery (BS) and caloric restriction are not fully understood but contribute to variable improvements in insulin sensitivity and cardiometabolic health. This study compared changes in insulin sensitivity and plasma concentrations of gut peptides 8 weeks and 1 year after BS and a low-calorie diet (LCD). Nineteen female patients with obesity self-selected BS (gastric bypass [n = 5] or sleeve gastrectomy [n = 7]) or LCD (n = 7) in this parallel-arm, prospective observational study.

Assessing spatial structure in marine populations using network theory: A case study of Atlantic sea scallop (Placopecten magellanicus) connectivity.

Knowledge of the geographic distribution and connectivity of marine populations is essential for ecological understanding and informing management. Previous works have assessed spatial structure by quantifying exchange using Lagrangian particle-tracking simulations, but their scope of analysis is limited by their use of predefined subpopulations. To instead delineate subpopulations emerging naturally from marine population connectivity, we interpret this connectivity as a network, enabling the use of powerful analytic tools from the field of network theory.

Fetuin B in white adipose tissue induces inflammation and is associated with peripheral insulin resistance in mice and humans.

Objective: Fetuin B is a steatosis-responsive hepatokine that causes glucose intolerance in mice, but the underlying mechanisms remain incompletely described. This study aimed to elucidate the mechanisms of action of fetuin B by investigating its putative effects on white adipose tissue metabolism.

Methods: First, fetuin B gene and protein expression was measured in multiple organs in mice and in cultured adipocytes.

Simulating Lagrangian Subgrid-Scale Dispersion on Neutral Surfaces in the Ocean.

To capture the effects of mesoscale turbulent eddies, coarse-resolution Eulerian ocean models resort to tracer diffusion parameterizations. Likewise, the effect of eddy dispersion needs to be parameterized when computing Lagrangian pathways using coarse flow fields. Dispersion in Lagrangian simulations is traditionally parameterized by random walks, equivalent to diffusion in Eulerian models.

Fecal carriage of antibiotic resistance gene affects adipose tissue function under vancomycin use.

Detrimental consequences of antibiotic treatment may include long-lasting disruption of the gut microbiota. Previous studies found no negative effects of antibiotics on metabolic health, although individualized responses were observed. Here, we aimed to investigate the subject-specific response to vancomycin use in tissue-specific insulin sensitivity by stratifying individuals based on the presence of antibiotic resistance genes (ARGs) or opportunistic pathogens (OPs) in the baseline fecal microbiota.