Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit.

Neuroglial cell death was investigated in 3 white matter tracts of jimpy and normal mice. In normal animals, glial death during development ranged from 0.5 to 2.

An evaluation of the tissue pH electrode for fetal monitoring using the fetal sheep as an experimental model.

The performance of the Roche tissue pH electrode has been assessed by comparison of values recorded by the the electrode with the pH of arterial blood, in fetal sheep. Observations were made under controlled conditions when the fetal pH was steady, during hypoxia, and after hypoxia. The results showed a highly significant correlation of the values recorded by the electrodes with the pH of arterial blood (r = 0.

The relationship between tissue and arterial pH in hypercarbic rabbits.

Continuous tissue pH and intermittent central arterial pH were measured in six rabbits during 10-min exposures to a mixture of 10% CO2 and 90% O2. In control and recovery situations tissue pH was more acidic than arterial pH by a mean value of 0.07 pH units.

Fundamental basis of tissue pH measurement.

The first tissue pH electrode is described and illustrated and notable features are commented on. Calibration procedure is discussed particularly concerning the need for temperature control. Experience with early examples of the tissue electrode is described and its performance with an independent pH monitoring and recording system assessed.

Sources of error in glucose determinations in neonatal blood by glucose oxidase methods, including Dextrostix.

An investigation was carried out to examine why a glucose oxidase-peroxidase-orthodianisidine method for plasma glucose, without protein precipitation, gave low results for neonatal blood. The magnitude of the difference between the results with and without protein precipitation was examined in a clinical neonatal series, and in sera to which bilirubin, hemolysate, pure hemoglobin, and uric acid had been added. Systematic linear inhibition was demonstrated with bilirubin, and the results suggested that high concentrations of hemolysate and uric acid could also interfere.