A Cross-Species Atlas of the Dorsal Vagal Complex Reveals Neural Mediators of Cagrilintide's Effects on Energy Balance.

Amylin analogs, including potential anti-obesity therapies like cagrilintide, act on neurons in the brainstem dorsal vagal complex (DVC) that express calcitonin receptors (CALCR). These receptors, often combined with receptor activity-modifying proteins (RAMPs), mediate the suppression of food intake and body weight. To understand the molecular and neural mechanisms of cagrilintide action, we used single-nucleus RNA sequencing to define 89 cell populations across the rat, mouse, and non-human primate caudal brainstem.

Collaboration Across Disciplines to Integrate Clinical Expertise into Medical Software Development: The Approach of the Dedalus Medical Office.

Medical informatics is a multidisciplinary field combining clinical and technical expertise. Addressing the challenge of aligning software design with clinicians' real-world needs, Dedalus established the Medical Office, a dedicated department designed to integrate clinical expertise directly into the software development process, in 2022. This paper details the approach and impact of the Medical Office.

Enhancing Clinical Practice: Creating Dynamic Medical Content in Electronic Medical Records.

The integration of Electronic Medical Records (EMRs) revolutionized healthcare but often retained limitations from paper-based structures. This study proposes a framework for developing dynamic medical content specifically adapted to the clinical context including medical specialty and diseases. Tailoring content to this dynamic context offers several benefits, including improved access to relevant information, streamlined workflows, and potentially better patient outcomes.