Publications by authors named "D Ramsden"
Socioeconomic factors have been associated with an increased need for manipulation under anesthesia (MUA) following total knee arthroplasty (TKA). The purpose of this study was to compare the rate of MUA and range of motion (ROM) following primary TKA in English and non-English-speaking patients. The authors conducted a retrospective cohort study of all primary TKAs performed at their institution between 2010 and 2017.
View Article and Find Full Text PDFPhysiologically-based pharmacokinetic (PBPK) modeling offers a viable approach to predict induction drug-drug interactions (DDIs) with the potential to streamline or reduce clinical trial burden if predictions can be made with sufficient confidence. In the current work, the ability to predict the effect of rifampin, a well-characterized strong CYP3A4 inducer, on 20 CYP3A probes with publicly available PBPK models (often developed using a workflow with optimization following a strong inhibitor DDI study to gain confidence in fraction metabolized by CYP3A4, f, and fraction available after intestinal metabolism, Fg), was assessed. Substrates with a range of f (0.
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- The study investigates how mutations in the LRRK2 gene, linked to Parkinson's disease, affect mitochondrial function and calcium signaling during stress-induced cell damage.
- In experiments, the researchers found that while wild-type cells exhibited a normal calcium surge in response to mitochondrial depolarization, LRRK2 mutant cells did not, indicating a disruption in the cellular response to damage.
- Further analysis showed that this lack of response in mutant cells was associated with impaired activation of key kinases involved in the stress response, leading to swollen mitochondria and overall mitochondrial dysfunction.
Objectives: The aim of this study was to investigate the pharmacokinetics (PK) of poorly soluble compounds when administered intramuscularly (i.m.) as crystalline particles of different sizes.
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- Cas9 is a powerful genome-editing tool used in biomedical research, but its interaction with mammalian cells and regulatory mechanisms is not well understood.
- Researchers identified Keap1 as an E3 ligase in mammals that targets Cas9 and its variants for degradation through a specific signal, impacting their effectiveness.
- By creating Cas9 mutants that avoid Keap1 recognition, the study shows improved gene editing capabilities and less disruption of Keap1's normal function, offering potential for more efficient gene regulation.