Publications by authors named "D Ramogola-Masire"
Objective: To evaluate the impact of ART duration and CD4 count on risk for high grade cervical dysplasia in women with HIV (WWH) compared to women without HIV in the treat-all era with integrase strand inhibitors (INSTIs).
Design: Prospective longitudinal cohort study in Botswana.
Methods: From February 2021 to August 2022, baseline HPV self-sampling was offered to women with and without HIV.
Background: Delays and missed opportunities for timely treatment contribute significantly to stark inequities in cervical cancer mortality in low- and middle-income countries (LMICs) compared to high-income countries. The vast majority (approximately 90%) of new cases and deaths occur in LMICs, particularly those with high rates of HIV such as Botswana. To date, most of the implementation and cancer control research in Botswana and other LMICs has focused on cancer prevention and screening, with limited focus on cancer treatment.
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- International guidelines suggest stopping cervical screenings at age 50 if two consecutive tests are negative, but many women over 50 in LMICs, like Botswana, haven't had the chance to screen.
- The study analyzed data from two separate cohorts—one for screening with 2,570 women aged 30+ and another with 1,520 cervical cancer patients—to understand the prevalence of cervical dysplasia and cancer stages by age and HIV status.
- Results showed similar prevalence rates of cervical intraepithelial neoplasia (CIN) between women aged 30-49 and 50+, regardless of HIV status, indicating no significant differences in disease prevalence across these age groups.
Background: Cervical cancer associated with human papillomavirus has the highest cancer incidence and mortality for women in Botswana because of a high HIV prevalence and limited screening. This study investigates the significance of HIV on the overall survival (OS) of patients with locally advanced cervical cancer by various treatment categories (curative chemoradiation, definitive radiation [RT] alone, or palliative RT alone).
Methods: This study included patients diagnosed with cervical cancer between 2013 and 2020, prospectively enrolled in the Botswana Prospective Cancer Cohort.