Publications by authors named "D Ramini"
Article Synopsis
- Endothelial cellular senescence is linked to age-related vascular dysfunction, with changes in the glycocalyx and shedding of syndecan-4 (SDC4) noted in various age-related diseases.
- An in vitro study showed that inflammation and replicative senescence increased SDC4 expression and shedding in human endothelial cells, while analysis of plasma SDC4 levels in diabetic and healthy subjects revealed significant differences linked to cardiovascular events.
- High plasma levels of SDC4 in subjects with type 2 diabetes without complications were associated with lower risk of major adverse cardiovascular events (MACE), suggesting SDC4 could potentially serve as a prognostic marker for cardiovascular issues over time.
Background: Individuals with type 2 diabetes (T2D) face an increased mortality risk, not fully captured by canonical risk factors. Biological age estimation through DNA methylation (DNAm), i.e.
View Article and Find Full Text PDFBackground: People are living longer but an increasing number of older people experience chronicity and disability in the latest years of their life. The Marche region is one of the Italian regions where people live the longest lives; therefore, the number of people with age-related chronic diseases is expected to be at least similar, if not higher, compared to the rest of Italy. The identification of the aging trajectories is of huge interest in the arena of public health.
View Article and Find Full Text PDFRecent literature shows that loss of replicative ability and acquisition of a proinflammatory secretory phenotype in senescent cells is coupled with the build-in of nucleic acids in the cytoplasm. Its implication in human age-related diseases is under scrutiny. In human endothelial cells (ECs), we assessed the accumulation of intracellular nucleic acids during in vitro replicative senescence and after exposure to high glucose concentrations, which mimic an in vivo condition of hyperglycemia.
View Article and Find Full Text PDFCellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments. Albeit in a state of permanent growth arrest, senescent cells paradoxically display a high metabolic activity.
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