Targeting Blood-Stage Malaria: Design, Synthesis, Characterization, In Vitro, and In Silico Evaluation of Pyrrolidinodiazenyl Chalcones.

Malaria is a pervasive and deadly threat to the global population, and the resources available to treat this disease are limited. There is widespread clinical resistance to the most commonly prescribed antimalarial drugs. To address this issue, we synthesized a range of 4'-pyrrolidinodiazenyl chalcones using a covalent bitherapy approach to study their potential antimalarial properties.

A Comparative randomised controlled trial of Homeopathy -vs- Allopathy in Acute Otitis Media and its recurrence in Children.

Objective: This study evaluates the efficacy of homeopathic treatments for Acute Otitis Media (AOM) in children, comparing outcomes to standard allopathic treatments. Building on promising pilot study results that suggested homeopathy's non-inferiority, this multicenter trial aims to validate these findings and assess their broader clinical applicability.

Method: This open-label, randomized controlled trial was conducted on children (aged 02 to 12 years), suffering from acute otitis media.

The Influence of Coccygeal Dynamic Patterns in Ganglion Impar Block for the Treatment of Chronic Refractory Coccydynia.

Introduction: Patients with persistent coccygodynia who do not respond to conventional therapies may undergo ganglion impar block (GIB). We looked at how GIB therapy for individuals with persistent coccygodynia affected their coccygeal dynamic patterns.

Materials And Methods: Patients with persistent coccydynia with GIB once using a trans-Sacro-coccygeal technique with fluoroscopy supervision were taken up for the study.

Site of breast cancer metastasis is independent of single nutrient levels.

Cancer metastasis is a major contributor to patient morbidity and mortality, yet the factors that determine the organs where cancers can metastasize are incompletely understood. In this study, we quantify the absolute levels of over 100 nutrients available across multiple tissues in mice and investigate how this relates to the ability of breast cancer cells to grow in different organs. We engineered breast cancer cells with broad metastatic potential to be auxotrophic for specific nutrients and assessed their ability to colonize different organs.