Gamma frequency connectivity in frontostriatal networks associated with social preference is reduced with traumatic brain injury.

Among the myriad of complications associated with traumatic brain injury (TBI), impairments in social behaviors and cognition have emerged as a significant area of concern. Animal models of social behavior are necessary to explore the underlying brain mechanisms contributing to chronic social impairments following brain injury. Here, we utilize large-scale brain recordings of local field potentials to identify neural signatures linked with social preference deficits following frontal brain injury.

Resting state EEG source derived salience network theta connectivity mediates anxiety in community dwelling individuals reporting childhood trauma.

Childhood trauma (CT) has been consistently linked with etiology of anxiety and depression. Finding biomarkers that mediate the relationship between CT and psychopathology is important and electroencephalography (EEG) can be a useful and cost-effective tool serving this purpose. Hence, in the current research we investigated resting state EEG biomarkers associated with CT and how these may link to psychopathology of anxiety and depression in adults.

Tumor seeding across specialties: a systematic review.

Background: Understanding shared characteristics underlying reported tumor seeding episodes can reveal when tumor seeding is most likely to occur and guide clinical decision making. Our goal was to systematically review tumor seeding across specialties and determine what types of instrumentation and primary tumor histology are associated with tumor seeding.

Methods: A systematic review was conducted using PubMed and Web of Science, per PRISMA guidelines.

Modulation of Posterior Default Mode Network Activity During Interoceptive Attention and Relation to Mindfulness.

Background: Interoceptive attention to internal sensory signals, such as the breath, is fundamental to mindfulness. However, interoceptive attention can be difficult to study, with many studies relying on subjective and retrospective measures. Response consistency is an established method for evaluating variability of attention on exteroceptive attention tasks, but it has rarely been applied to interoceptive attention tasks.

Intermittent Theta Burst Stimulation Drives Bi-Directional Changes in Excitability in Prefrontal Cortex.

Theta burst stimulation (TBS), an FDA-cleared treatment for depression, is hypothesized to modulate excitability in the prefrontal cortex, though this has not definitively been shown in vivo. We performed calcium imaging on glutamatergic neurons in awake rodents to understand the effects of theta burst stimulation at a cellular level. Our findings provide the first direct evidence that TBS bidirectionally modulates glutamatergic activity when delivered in vivo and directly links calcium activity changes during stimulation with post-stimulation plasticity.