Publications by authors named "D Rajagopal"
Glucagon-like peptide-1 (GLP-1) receptor agonists have drawn a lot of interest lately for their therapeutic advantages over controlling blood sugar levels in the management of type 2 diabetes mellitus (T2DM). This review aims to provide an overview of the research that has been done on the neuroprotective, renoprotective, and cardioprotective effects of GLP-1 receptor agonists. Studies suggest that these medicines could provide protective benefits beyond glucose regulation, possibly reducing the risks of cardiovascular and renal issues; mechanisms underlying these advantages are still not fully understood.
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- The study explores how specific human leukocyte antigen (HLA) alleles influence the risk of skin reactions to certain drugs by examining their interaction patterns.
- Four drugs (phenytoin, amoxicillin, aceclofenac, and ciprofloxacin) were tested for docking behavior against four HLA alleles using computational methods, revealing insights into their binding energies and potential toxicity.
- Results indicate that amoxicillin and ciprofloxacin may cause liver damage, and phenytoin showed the lowest binding energy with the tested HLA alleles, which may lead to skin-related adverse effects.
Recombinant antibodies (Abs) are an integral modality for the treatment of multiple tumour malignancies. Since the Food and Drug Administration (FDA) approval of rituximab as the first monoclonal antibody (mAb) for cancer treatment, several mAbs and antibody (Ab)-based therapies have been approved for the treatment of solid tumour malignancies and other cancers. These Abs function by either blocking oncogenic pathways or angiogenesis, modulating immune response, or by delivering a conjugated drug.
View Article and Find Full Text PDFBackground Sivelestat is a potent and specific neutrophil elastase inhibitor. It is clinically used in treating lung injury and respiratory distress syndrome. This engaged us to undertake the present study in which sivelestat was studied as an anti-inflammatory and anti-viral agent.
View Article and Find Full Text PDFDevelopment of functional tricuspid regurgitation (TR) because of chronic mitral disease and subsequent heart failure is common. However, the effect of TR on clinical outcomes after transcatheter mitral valve replacement (TMVR) remains unclear. We aimed to evaluate the impact of baseline TR on outcomes after TMVR.
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