Phosphine-Stabilized Pnictinidenes.

The reaction of the intramolecular germylene-phosphine Lewis pair (o-PPh )C H GeAr* (1) with Group 15 element trichlorides ECl (E=P, As, Sb) was investigated. After oxidative addition, the resulting compounds (o-PPh )C H (Ar*)Ge(Cl)ECl (2: E=P, 3: E=As, 4: E=Sb) were reduced by using sodium metal or LiHBEt . The molecular structures of the phosphine-stabilized phosphinidene (o-PPh )C H (Ar*)Ge(Cl)P (5), arsinidene (o-PPh )C H (Ar*)Ge(Cl)As (6) and stibinidene (o-PPh )C H (Ar*)Ge(Cl)Sb (7) are presented; they feature a two-coordinate low-valent Group 15 element.

Phosphine-Stabilized Germasilenylidene: Source for a Silicon-Atom Transfer.

A phosphine-stabilized germasilenylidene is synthesized following the pathway of SiCl oxidative addition at a germylene-phosphine Lewis pair. Low-temperature reduction using {(Nacnac)Mg} resulted in a chlorosilylene intermediate and finally a molecule exhibiting a Ge═Si: motif. Inside the chelating phosphine-germylene, a low-valent silicon atom is stabilized and was transferred to diazabutadiene to give N-heterocyclic silylenes.

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.

Diamond-Blackfan anemia (DBA) is a rare hematopoietic disease characterized by a block in red cell differentiation. Most DBA cases are caused by mutations in ribosomal proteins and characterized by higher than normal activity of the tumor suppressor p53. Higher p53 activity is thought to contribute to DBA phenotypes by inducing apoptosis during red blood cell differentiation.

Germaborenes: Borylene Transfer Agents for the Synthesis of Iminoboranes.

Halide and phenyl substituted germaborenes were shown to react with azides at room temperature and transfer a borylene moiety to give iminoboranes. This iminoborane synthesis based on a borylene transfer route was investigated computationally in the case of the phenyl substituted germaborene.