Publications by authors named "D Rademaker"
Article Synopsis
- The interaction between peptides and MHC molecules is crucial for understanding autoimmunity and improving cancer immunotherapies.
- Recent advancements reveal that traditional sequence-based prediction methods have limitations, prompting the need for better approaches.
- The new structure-based methods, utilizing geometric deep learning and self-supervised learning, show improved accuracy and efficiency in predicting MHC-bound peptides, even outperforming conventional methods with significantly less data.
Sustainable alternatives for the energy intensive synthesis of HO are necessary. Molecular cobalt catalysts show potential but are typically restricted by undesired bimolecular pathways leading to the breakdown of both HO and the catalyst. The confinement of cobalt porphyrins in the PCN-224 metal-organic framework leads to an enhanced selectivity towards HO and stability of the catalyst.
View Article and Find Full Text PDFThe WHO 2013 oral glucose tolerance test: The utility of isolated glucose measurements - A retrospective cohort study.
Eur J Obstet Gynecol Reprod Biol
May 2024
Objective: The WHO 2013 guidelines recommend screening for gestational diabetes mellitus (GDM) by 3-point oral glucose tolerance test (OGTT). The objective of this retrospective cohort study was to evaluate GDM diagnosed by an isolated high glucose.
Study Design: We included pregnant women deemed at risk for GDM were offered GDM screening.
Several hematologic diseases, including malaria, diabetes, and sickle cell anemia, result in a reduced red blood cell deformability. This deformability can be measured using a microfluidic device with channels of varying width. Nevertheless, it is challenging to algorithmically recognize large numbers of red blood cells and quantify their deformability from image data.
View Article and Find Full Text PDFAims: The impact of maternal metformin use during pregnancy on fetal, infant, childhood and adolescent growth, development, and health remains unclear. Our objective was to systematically review the available evidence from animal experiments on the effects of intrauterine metformin exposure on offspring's anthropometric, cardiovascular and metabolic outcomes.
Methods: A systematic search was conducted in PUBMED and EMBASE from inception (searched on 12th April 2023).