Mechanically robust, mouldable, dynamically crosslinked hydrogel flap with multiple functionalities for accelerated deep skin wound healing.

Deep cutaneous wounds, which are difficult to heal and specifically occur on dynamic body surfaces, remain a substantial healthcare challenge in clinical practice because of multiple underlying factors, including excessive reactive oxygen species, potential bacterial infection, and extensive degradation of the extracellular matrix (ECM) which further leads to the progressive deterioration of the wound microenvironment. Any available individual wound therapy, such as antibiotic-loaded cotton gauze, cannot address all these issues. Engineering an advanced multifunctional wound dressing is the current need to promote the overall healing process of such wounds.

Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology.

A significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative to synthetic antibiotics.

Association of frailty with non-laboratory based cardiovascular disease risk score among older adults and elderly population: insights from longitudinal aging study in India (LASI-1st wave).

Introduction: Frailty is an inevitable part of ageing, which is also associated with a variety of chronic diseases, the most common of which are cardiovascular diseases. The WHO non-laboratory-based CVD risk scores are reliable predictors of cardiovascular events and are used in treatment decision-making in primary health-care settings. The current study aims to find the association between the non-laboratory-based CVD risk scores and frailty scores.

Efficacy of molecularly diversified phosphorus-solubilizing rhizobacterial isolates in phytostimulation, antimicrobial attributes and phosphorus-transporter genes mediated plant growth performance in maize (Zea mays L.).

This study evaluated a dual management approach to enhance plant-growth by improving soil fertility, reducing pathogenic stress using PGPR that affect phosphorus-transporter (pht) genes. Among 213 maize rhizobacterial isolates, 40 demonstrated the ability to solubilize tri-calcium phosphate, potassium, zinc, and silicon, showing various PGP traits. Nine of these isolates exhibited significant antagonistic activity against the plant pathogens Colletotrichum chlorophyti and Xanthomonas axonopodis.

Itaconate mechanism of action and dissimilation in .

Itaconate, an abundant metabolite produced by macrophages upon interferon-γ stimulation, possesses both antibacterial and immunomodulatory properties. Despite its crucial role in immunity and antimicrobial control, its mechanism of action and dissimilation are poorly understood. Here, we demonstrate that infection of mice with increases itaconate levels in lung tissues.