Worldsheet Correlators in Black Hole Microstates.

Light probes interacting with heavy bound states such as black holes give rise to observables containing valuable dynamical information. Recently, a family of black hole microstates was shown to admit an exact string worldsheet description. We construct the physical vertex operators of these models, and compute an extensive set of novel heavy-light correlators.

Will clinical signs become myth? Developing structured Signs Circuits to improve medical students' exposure to and confidence examining clinical signs.

Background: Correctly eliciting and interpreting physical examination (PEx) signs contributes to successful diagnosis and is fundamental to patient care. A significant decline in the time spent acquiring these skills by medical students, and the decreased ability to elicit and recognise signs is widely acknowledged. However, organising teaching to counteract this in the busy clinical environment is challenging.

New Fully Automated Preparation of High Apparent Molar Activity Ga-FAPI-46 on a Trasis AiO Platform.

A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, Ga-FAPI-46 was reported to have a high specificity and affinity for FAP-expressing cells, a fast and high accumulation in tumor lesions/injuries together with a fast body clearance when investigated in vivo. Due to the increasing interest in the use of the agent both preclinically and clinically, we developed an automated synthesis for the production of Ga-FAPI-46 on a Trasis AiO platform.

F-meta-fluorobenzylguanidine (F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models.

Targeted radiotherapy with I-mIBG, a substrate of the human norepinephrine transporter (NET-1), shows promising responses in heavily pre-treated neuroblastoma (NB) patients. Combinatorial approaches that enhance I-mIBG tumour uptake are of substantial clinical interest but biomarkers of response are needed. Here, we investigate the potential of F-mFBG, a positron emission tomography (PET) analogue of the I-mIBG radiotracer, to quantify NET-1 expression levels in mouse models of NB following treatment with AZD2014, a dual mTOR inhibitor.

A typology of laterals in twelve English dialects.

Allophonic patterns of variation in English laterals have been well studied in phonetics and phonology for decades, but establishing broad generalizations across varieties has proven challenging. In this study, a typology of onset/coda lateral distinctions in English is advanced using crowdsourced recordings from 95 speakers across twelve dialects of Anglo (UK) English. Results confirm the existence of dialects with and without onset/coda distinctions, and conditional inference trees are used to identify three main patterns in the data: (1) clear onsets and dark codas; (2) intermediate/dark onsets and dark codas, but with a positional distinction intact; and (3) dark onsets and dark codas, with minimal or no distinctions between positions.