Publications by authors named "D R Towner"
Background: Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the intergenerational effect of maternal obesity, we hypothesized that the maternal obesity effect is mediated by epigenetic changes in the CD34+/CD38-/Lin- hematopoietic stem cells (uHSCs) in the offspring. Towards this, we conducted a DNA methylation centric multi-omics study.
View Article and Find Full Text PDFObjective: This study aimed to compare cesarean delivery (CD) rates and maternal/neonatal outcomes before and after the 2014 ACOG/SMFM Obstetric Care Consensus for Safe Prevention of Primary CD.
Study Design: This retrospective study compared unscheduled CD rates and outcomes of singleton, cephalic, term pregnancies at a tertiary-care teaching maternity hospital. Births 5 years before (March 2009-February 2014) and after (June 2014-May 2019) release of the consensus were included.
Article Synopsis
- Alpha thalassemia major (ATM) poses a high risk of perinatal loss without in utero transfusions (IUTs), prompting an international registry to assess the impact of IUTs on survival and neurodevelopmental outcomes.
- Among 49 prenatally diagnosed patients, those who received IUTs had significantly better health outcomes, such as resolution of hydrops and shorter hospital stays, compared to those diagnosed postnatally.
- Data suggested that the earlier the IUT started, the better the neurodevelopmental scores, highlighting the importance of IUTs in improving survival and normal development in ATM patients, and suggesting that prenatal counseling should include this option for expectant parents.
Objectives: Early diagnosis of gestational diabetes can lead to greater optimization of glucose control. We evaluated associations between maternal serum analytes (alpha-fetoprotein [AFP], free beta-human chorionic gonadotropin [beta-hCG], inhibin, and estriol) and the development of gestational diabetes mellitus (GDM).
Methods: This retrospective cohort study identified single-ton pregnancies with available second trimester serum analytes between 2009 and 2017.
COVID-19 pandemic is changing profoundly the obstetrics and gynecology (OB/GYN) academic clinical learning environment in many different ways. Rapid developments affecting our learners, patients, faculty and staff require unprecedented collaboration and quick, deeply consequential readjustments, almost on a daily basis. We summarized here our experiences, opportunities, challenges and lessons learned and outline how to move forward.
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