G1P3/IFI6, an interferon stimulated protein, promotes the association of RAB5 endosomes with mitochondria in breast cancer cells.

G1P3/IFI6 is an interferon stimulated gene with antiapoptotic, prometastatic, and antiviral functions. Despite its pleiotropic functions, subcellular localization of G1P3 remains unclear. Using biochemical- and confocal microscopic approaches, this study identified the localization of G1P3 in organelles of the endomembrane system and in the mitochondria of breast cancer cells.

Neomycin-induced deafness in neonatal mice.

Background: Hearing impairment is a rising public health issue, and current therapeutics fail to restore normal auditory sensation. Animal models are essential to a better understanding of the pathophysiology of deafness and developing therapeutics to restore hearing.

New Methods: Wild-type CBA/CaJ neonatal mice P2-5 were used in this study.

Neglected wooden foreign body in the parotid gland: A case report.

Foreign body anywhere in the body can be a diagnostic challenge to a doctor, especially if it is wooden and hardly symptomatic. A foreign body in the parotid gland, whether from the oral cavity or through the skin is extremely uncommon. We are presenting a case of a wooden foreign body in the parotid gland of a 61-year-old patient who did not want to be examined or treated initially as it was not causing him any troublesome symptoms.

Participatory Approach to Develop Evidence-Based Clinical Ethics Guidelines for the Care of COVID-19 Patients: A Mixed Method Study From Nepal.

During health emergencies such as the COVID-19 pandemic, healthcare workers face numerous ethical challenges while catering to the needs of patients in healthcare settings. Although the data recapitulating high-income countries ethics frameworks are available, the challenges faced by clinicians in resource-limited settings of low- and middle-income countries are not discussed widely due to a lack of baseline data or evidence. The Nepali healthcare system, which is chronically understaffed and underequipped, was severely affected by the COVID-19 pandemic in its capacity to manage health services and resources for needy patients, leading to ethical dilemmas and challenges during clinical practice.