Safety and efficacy of three alternative regimens against relapsing Plasmodium vivax malaria in glucose 6-phosphate dehydrogenase deficient patients in the Brazilian Amazon (ALTPRIM).

Background: Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed.

Methods: G6PDd participants with P.

Microplastics in commercial marine bivalves: Abundance, characterization and main effects of single and combined exposure.

Microplastics (MPs) are persistent and ubiquitous pollutants in marine ecosystems, and they can be ingested and accumulated by marine organisms with economic value to humans, such as marine bivalves, which may pose a threat to the marine food chains and to human health. In this literature review, we summarized the recent findings on the abundance and main characteristics (shape, size, color, polymer) of MPs detected in valuable marine bivalve species. Furthermore, we surveyed the major impacts triggered by MP exposure, alone or in combination with other pollutants, in these organisms.

Prognosis Associated with Complete Pathological Response Following Neoadjuvant Treatment for PancreaTic AdenOcarciNOma in the FOFLIRINOX Era: the Multicenter TONO Study.

Background: The use of multiagent FOLFIRINOX chemotherapy for pancreatic adenocarcinoma in a neoadjuvant setting has been associated with an increased rate of complete pathological response (CPR) after surgery. This study investigated the long-term outcomes of patients with CPR in a multicenter setting to identify prognostic factors for overall survival (OS) and recurrence-free survival (RFS).

Methods: This retrospective cohort study examined biopsy-proven pancreatic adenocarcinomas with CPR after neoadjuvant chemotherapy or chemoradiotherapy and surgery, between January 2006 and December 2023 across 22 French and  2 Belgian centers.

Factors associated with hypercholesterolemia in older adults: A cross-sectional investigation.

Objective: To investigate the factors associated with hypercholesterolemia in older adults residing in a small municipality in northeastern Brazil.

Methods: This is a population-based cross-sectional epidemiological study conducted with 232 older adults (women: 58.60%; men: 41.

"You find yourself in a very humiliating situation": experiences of people living with post-tuberculosis lung disease in Brazil.

Background: Brazil remains one of the 30 countries with the highest tuberculosis (TB) and TB-HIV coinfection burden. Post-TB lung disease (PTLD) is a set of sequelae that can occur in people who have been cured of TB.

Aim: To learn about the experiences of people living with PTLD (PLPTLD) and how healthcare workers (HCW) manage PTLD.