Publications by authors named "D R Rubinow"
Hyperactive and hyperreactive HPA axis functions are frequently reported in depressive disorders, particularly in major depression. However, research into HPA axis function in women with premenstrual dysphoric disorder (PMDD), which is also classified as a depressive disorder, has shown inconsistent results. This study aimed to characterize the HPA axis in women with PMDD using the combined dexamethasone suppression and CRH stimulation (Dex/CRH) test, alongside measurements of 24-hour urine free cortisol (UFC).
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- The study focuses on postpartum depression (PPD), a hereditary form of major depressive disorder, using genome-wide association studies (GWAS) to explore its genetic basis across various populations.
- It analyzed data from 18,770 PPD cases and 58,461 controls, finding no single-nucleotide polymorphisms (SNPs) that met genome-wide significance, though it highlighted significant genetic correlations with other mental health conditions.
- The findings suggest that PPD is polygenic and heritable, potentially involving unique genetic factors despite its close relationship with major depressive disorder and implicate specific brain neurons associated with its treatment.