Establishment and Characterization of Mild Atopic Dermatitis in the DNCB-Induced Mouse Model.

In dermatological research, 2,4-dinitrochlorbenzene (DNCB)-induced atopic dermatitis (AD) is a standard model as it displays many disease-associated characteristics of human AD. However, the reproducibility of the model is challenging due to the lack of information regarding the methodology and the description of the phenotype and endotype of the mimicked disease. In this study, a DNCB-induced mouse model was established with a detailed procedure description and classification of the AD human-like skin type.

Periodontal disease morbidity quantification. II. Validation of alveolar bone loss measurements and vertical defect diagnosis from digital bite-wing images.

Quantitative alveolar bone loss evaluation by digital processing of dental radiographs was performed. More than 20 contrast and edge enhancement techniques were applied to bite-wing radiographs of adult molar teeth and the results subjectively evaluated. Wallis space variant image enhancement was selected as the most promising candidate for improved visualization of the cemento-enamel junctions and alveolar crests.

Significance of apparent intratympanic meningiomas.

Meningioma is the most common tumor of the central nervous system, but it has only been reported in 79 patients to involve the temporal bone. The 4 cases presented here show striking clinical similarity to a subgroup of 20 meningiomas reported to be entirely intratympanic; however, in each instance the extent, origin, and potential of the disease was not initially evident. Precise histopathologic diagnosis may be aided by electron microscopy.