Publications by authors named "D R Regan"
Article Synopsis
- The high failure rate of surgical repairs for tendinopathies has led researchers to explore adjunct therapies, specifically exosomes (EVs) from mesenchymal stromal cells (MSCs) which have shown promise in animal studies for enhancing tendon healing.
- Research indicates that exosomes from tendon-specific cells (tenocytes) may be more effective than MSC-derived exosomes in promoting tendon healing due to their distinct functional properties.
- The study found that tenocyte-derived exosomes (TdEVs) altered macrophage responses in ways that support tendon healing, while MSC-derived exosomes triggered different pathways related to inflammation and oxidative stress, highlighting the importance of the source of EVs in tendon repair processes.
Perioperative medicine is an evolving field, with important publications each year across multiple disciplines. Staying up to date in the field is complicated due to the wide range of journals that publish relevant articles. This review summarizes the most noteworthy perioperative publications in 2023.
View Article and Find Full Text PDFNumerous proteins in nature strictly require oligomerization for their full activity. Moreover, the function of natural and artificial proteins can me adjusted by altering their oligomeric state, leading to development of biotechnologically-relevant biomacromolecules. Oligomerization scaffolds from natural sources and designed de novo enable shuffling the oligomeric state and valency of biomacromolecules.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the use of magnetic resonance elastography (MRE) as a non-invasive way to detect and measure liver fibrosis in a cancer model using Oncopigs.
- Seven Oncopigs were subjected to alcoholic liver fibrosis induction and underwent MRE imaging along with liver biopsies over three months to assess liver stiffness and fibrosis grading.
- Although MRE showed potential for detecting liver stiffness, histological analysis from biopsies was more effective in accurately identifying liver fibrosis, highlighting the need for further research in this area.