Publications by authors named "D R Mortensen"
In recent years, targeted protein degradation (TPD) has emerged as a powerful therapeutic modality utilizing both heterobifunctional ligand-directed degraders (LDDs) and molecular glues (e.g., CELMoDs) to recruit E3 ligases for inducing polyubiquitination and subsequent proteasomal degradation of target proteins.
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- The study aimed to compare the effectiveness of two scoring systems (Gorelick index and modified ICDAS II) for identifying white spot lesions (WSLs) in dental photographs taken during orthodontic treatment debonding.
- Researchers analyzed digital images from 58 healthy adolescents, focusing on 384 tooth surfaces evaluated independently by three trained examiners at separate times, finding that both scoring systems had a consistent positive correlation.
- Results indicated moderate to excellent reliability for the GI and moderate to good for ICDAS II, with strong agreement on sound surfaces and severe lesions, but variability among examiners for milder cases.