Publications by authors named "D R Mandel"
Clinical and neuroimaging patterns of perinatal intracranial haemorrhage in fetuses and term-born neonates: a prospective observational cohort study.
Moran Hausman-Kedem Stephanie Libzon Aviva Fattal Valevski Gustavo Malinger Nina Krajden Haratz Dror Mandel
Arch Dis Child Fetal Neonatal Ed
October 2024
Article Synopsis
- The study aimed to characterize perinatal intracranial hemorrhage (pICH), focusing on differences between cases diagnosed before and after birth and analyzing their causes and clinical patterns.
- Conducted over a decade, the research included 110 pICH cases, revealing that intraventricular hemorrhage (IVH) was most prevalent, particularly in prenatally diagnosed cases, while subpial hemorrhage was exclusively identified postnatally.
- The findings indicated that genetic disorders contributed to nearly a third of pICH cases, highlighting the necessity for next-generation sequencing to better understand genetic factors associated with prenatally diagnosed hemorrhages.
Article Synopsis
- Left ventricular diastolic dysfunction (LVDD) and elevated left ventricular filling pressure (LVFP) may be linked to clinical outcomes in stroke patients, but their specific role in embolic stroke of undetermined source (ESUS) needs further exploration.
- A study was conducted on adults with acute ischemic stroke to evaluate the relationship between LVDD, elevated LVFP, and stroke types, specifically comparing ESUS and non-cardioembolic stroke (NCE). Patients with cardioembolic strokes were excluded.
- Findings suggest that while LVDD alone isn't significantly related to ESUS or atrial fibrillation (AF), having LVDD with elevated LVFP shows a borderline association with ESUS and a significant association
Article Synopsis
- Cervical artery dissection (CeAD) is a leading cause of ischemic strokes in young adults, and this study explored the effects of intravenous thrombolysis (IVT) on patients with CeAD and stroke symptoms.
- Analyzed data from the STOP-CAD study, it found that IVT significantly improved functional independence after 90 days in patients without increasing the risk of symptomatic intracranial hemorrhage.
- The results suggest that IVT is a beneficial treatment for eligible patients with CeAD, aligning with current medical guidelines on its use.
Background: In-utero phthalate exposure was shown to be associated with shortened anogenital distance (AGD) in male newborns, but findings among female are inconsistent. While phthalate exposure among pregnant women in Israel is widespread, no study has examined the association with offspring AGD. The objective of the current study was to investigate the association between maternal phthalates urinary concentration and offspring AGD at time of delivery among a birth cohort in Israel.
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