Delayed effects of enalapril on structural characteristics of the glomerular apparatus in the kidneys of NISAG rats.

Structural characteristics of renal glomeruli were studied in adult hypertensive NISAG rats (hereditary stress-induced hypertension) receiving antihypertensive drug enalapril, an inhibitor of angiotensin-converting enzyme, on days 28-58 of life. Treatment with enalapril (25 mg/kg perorally) in the early period of postnatal ontogeny produced delayed hypotensive and nephroprotective effects.

Effect of neonatal handling in rats with hereditary stress-induced arterial hypertension (NISAG rats).

NISAG rats were subjected to handling on days 1-21 after birth. Blood pressure and plasma corticosterone concentration were measured in 6-month-old handled and control NISAG rats at rest and under stress conditions. Animal behavior was studied in the open-field test.

Effect of chronic stress during early postnatal ontogeny on structural characteristics of the myocardium and glomerular apparatus of the kidneys in NISAG rats.

We studied structural characteristics of the myocardium and glomerular apparatus of the kidneys in 3-week- and 6-month-old male NISAG rats (hereditary stress-induced arterial hypertension) subjected to handling on days 1-21 of postnatal ontogeny. The animals were daily isolated from mothers for 10 min. Handling did not modulate the development of arterial hypertension and typical morphological signs in the myocardium and kidneys.

Hypotensive effect of potentiated antibodies to angiotensin II and AT1 receptors.

Hypotensive activity of ultralow doses of antibodies to angiotensin II and its receptors was studied on adult NISAG rats with hereditary stress-induced arterial hypertension. Antibodies to C-terminal fragment of angiotensin II receptors produced the most pronounced hypotensive effect, which was reproducible after repeated administration. These antibodies decreased systolic blood pressure by 16.

Hypotensive activity of ultralow doses of antibodies to factors involved in the regulation of vascular tone.

Hypotensive activity of ultralow doses of antibodies to some endogenous substances involved in the regulation of vascular tone was studied on NISAG rats with hereditary stress-induced arterial hypertension. It was found that antibodies to angiotensin II and its receptor in ultralow doses markedly reduced systolic blood pressure, which was reproducible after repeated treatment. The course of peroral treatment with antibodies to endothelin and endothelial NO synthase in ultralow doses did not decrease systolic blood pressure.