Publications by authors named "D R HARTMAN"
Background: On demand, topical PrEP is desired by those preferring episodic, nonsystemic PrEP. PC-1005 gel (MIV-150, zinc, and carrageenan) exhibits in vitro antiviral HIV-1, human papillomavirus (HPV), and herpes simplex virus type 2 (HSV-2) activity, attractive for a multipurpose prevention technology candidate. We evaluated the safety, pharmacokinetics, and antiviral effect of rectally applied PC-1005.
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- * Out of 31 patients, 55% showed a significant drop in tumor activity (major pathologic response), along with increased immune cell presence in the tumors.
- * Findings indicate that this combination therapy not only activates various immune responses but is also linked to specific genetic markers in immune cells and changes in gut microbiota, suggesting potential pathways for enhancing treatment outcomes.
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- Human environmental DNA (eDNA) shows promise as a forensic tool for detecting human DNA in aquatic environments but hasn't been thoroughly utilized yet.
- A preliminary study tested the persistence and detection of human eDNA using water samples from both freshwater and saltwater, with results indicating varying degrees of detectability over time.
- The findings suggest that incorporating human eDNA analysis could significantly aid law enforcement in improving investigation accuracy, especially in cases linked to aquatic settings, but further research is essential for optimization.
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- The paper discusses the challenges of identifying human remains found at Sandy Point, Victoria, where both circumstantial information and preservation were lacking, complicating the identification process.
- Traditional methods like visual or fingerprint identification were impossible due to the state of the remains, leading to the use of a range of techniques including radiocarbon dating and genetic analysis.
- Ultimately, an interdisciplinary approach combining forensic anthropology, odontology, history, and genealogy successfully identified the remains as belonging to Christopher Luke Moore, who drowned in 1928.
The successful application of Forensic Investigative Genetic Genealogy (FIGG) to the identification of unidentified human remains and perpetrators of serious crime has led to a growing interest in its use internationally, including Australia. Routinely, FIGG has relied on the generation of high-density single nucleotide polymorphism (SNP) profiles from forensic samples using whole genome array (WGA) (∼650,000 or more SNPs) or whole genome sequencing (WGS) (millions of SNPs) for DNA segment-based comparisons in commercially available genealogy databases. To date, this approach has required DNA of a quality and quantity that is often not compatible with forensic samples.
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