Publications by authors named "D R Gutsaeva"
The current study tested the hypothesis of whether specific lipids may control angiogenic reactions. Using the chorioallantoic membrane assay of the chick embryo, new vessel formation was analyzed quantitatively by gas chromatography and mass spectrometry as well as bioinformatics tools including an angiogenesis analyzer. Our biochemical experiments showed that a specific lipid composition and stoichiometry determine the angiogenesis microenvironment to accelerate or inhibit vessel formation.
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- The study investigates the molecular mechanisms behind diabetic retinopathy (DR) by examining the interactions of proteins and metabolites, aiming to identify novel biomarkers for the condition.
- Using proteomic techniques and bioinformatics, researchers discovered new biomarkers related to DR and mapped the protein and metabolite networks involved in the disease.
- The findings indicate that mitochondrial dysfunction plays a significant role in DR progression, affecting various biological processes and suggesting possible therapeutic targets for treatment.
Article Synopsis
- Intense light exposure leads to retinal degeneration by generating reactive oxygen species and nitric oxide, resulting in abnormal cell death through apoptosis in diseases like diabetic retinopathy and age-related macular degeneration.
- Erythropoietin (EPO) has been studied for its potential to protect retinal cells from damage and regulate angiogenesis (formation of new blood vessels) during oxidative stress conditions.
- The research indicates that EPO might offer a new therapeutic approach for retinal degeneration by balancing anti-apoptotic and pro-angiogenic signals at the molecular level.
Article Synopsis
- The study used a metabolomics approach to identify natural molecules involved in angiogenesis (the formation of new blood vessels) through experiments on chick embryos.
- By analyzing the chicks' chorioallantoic membrane (CAM) and using gas chromatography-mass spectrometry (GCMS), researchers found that certain fatty acids, particularly oleic, cholesterol, and linoleic acids, increased during the early stages of vessel formation.
- The research suggests that these lipids may start the angiogenesis process, paving the way for other proteins like vascular endothelial growth factor to participate later in blood vessel development.
Retinal ischemia contributes to visual impairment in ischemic retinopathies. A disintegrin and metalloproteinase ADAM17 is implicated in multiple vascular pathologies through its ability to regulate inflammatory signaling via ectodomain shedding. We investigated the role of endothelial ADAM17 in neuronal and vascular degeneration associated with retinal ischemia reperfusion (IR) injury using mice with conditional inactivation of ADAM17 in vascular endothelium.
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