Publications by authors named "D R Grattan"
The prolactin receptor (Prlr) is widely expressed in the brain, particularly in the hypothalamus. Prolactin also has an increasing range of well-characterised effects on central nervous system function. Because of this, over many years, there has been interest in whether the hormone itself is also expressed within the brain, perhaps acting as a neuropeptide to regulate brain function via its receptor in neurons.
View Article and Find Full Text PDFArticle Synopsis
- β-Catenin is an important protein involved in Wnt signaling that affects gene expression and cellular processes, linking it to obesity and type-2 diabetes through interaction with TCF7L2.
- * Researchers investigated its role in regulating body weight and glucose levels by deleting β-catenin in specific brain regions in mice, observing their reactions to different diets.
- * Results showed that mice lacking β-catenin gained more weight on a high-fat diet due to lower energy expenditure and exhibited glucose intolerance, suggesting β-catenin's significant role in metabolism and potential links to metabolic diseases.*
Obesity during pregnancy represents a significant health issue and can lead to increased complications during pregnancy and impairments with breastfeeding, along with long-term negative health consequences for both mother and offspring. In rodent models, diet-induced obesity (DIO) during pregnancy leads to poor outcomes for offspring. Using a DIO mouse model, consisting of feeding mice a high fat diet for 8 weeks before mating, we recapitulate the effect of high pup mortality within the first 3 days postpartum.
View Article and Find Full Text PDF