Publications by authors named "D R Fullen"
A man in his 60s suffered from refractory, biopsy-proven subacute cutaneous lupus erythematosus that required chronic, moderate dose steroids to manage. His rash was accompanied by arthralgias and negative autoantibody testing. His subacute lupus erythematosus (SCLE) was responsive to tofacitinib, but thrombotic complications limited the use of this medication.
View Article and Find Full Text PDFClinical Molecular Testing for Clonal Relatedness of Second Melanoma Tumors.
Arch Pathol Lab Med
December 2024
Context.—: Patients with melanoma can develop second tumors representing either metastases or new primary melanoma. This distinction has profound implications for management.
View Article and Find Full Text PDFArticle Synopsis
- Squamoid eccrine ductal carcinoma is a rare tumor with characteristics that fall between squamous cell carcinoma (SCC) and certain sweat gland carcinomas, leading to debates on its classification.
- The study examined 15 cases of this carcinoma, revealing that most cases had UV signature mutations and TP53 mutations as the most common genetic alterations.
- Transcriptome analysis indicated that this carcinoma expresses 364 genes more and 525 genes less compared to SCC and sweat gland tumors, reinforcing the idea that it has an intermediate phenotype between these cancer types.
Article Synopsis
- Inverted follicular keratosis (IFK) is typically a harmless skin tumor, but some cases have presented similarly on genital skin with characteristics that could suggest squamous cell carcinoma (SCC).
- In a study of four young women with these genital tumors, researchers found distinct histopathological features indicating a non-invasive growth pattern, without signs of SCC, and confirmed the diagnosis through various tests.
- The findings led the authors to suggest calling these cases "proliferating IFK" to clarify that they are a variant of IFK and to prevent misdiagnosis as SCC.