Theories of Arousal Predict a Link Between Heart Rate Variability and Reactive Aggression: Meta-Analytic Results Disagree.

Polyvagal theory posits that habitually aggressive individuals might have an impaired capacity to calm after arousal, which has led to the investigation of Arousal-based biological indicators - "biomarkers" - of aggression, to identify individuals at high risk. The most popular approach in research examining (specifically reactive) aggression is the use of wearable technologies that can non-invasively measure heart rate variability (HRV), a cardiovascular phenomenon impacted by activation of the parasympathetic ("rest and digest") nervous system. But there is a problem: no one has systematically analyzed the results of these studies to determine if HRV is an effective predictor of reactive aggression.

Selinexor in combination with dexamethasone with or without bortezomib in heavily pretreated multiple myeloma: A case series.

This report describes the characteristics and outcomes of 18 heavily pretreated patients with multiple myeloma (MM) who were subsequently treated with selinexor. This is a case series of 18 patients with MM who were treated with selinexor and dexamethasone (Sd) or selinexor, bortezomib, and dexamethasone (SVd) in 12 hospitals in the UK between 2019 and 2021. Eight patients received Sd and 10 patients received SVd.